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IMPaCT Trial

Individualised Molecular Pancreatic Cancer Therapy (IMPaCT) is a new clinical trial looking at individualising the treatment of patients with metastatic pancreatic cancer.

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Familial Cancer Cohort

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Publications

We are seeing great progress in pancreatic cancer research and the APGI and it's collaborators are at the heart of this.

Journal Articles Published

  1. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Biankin AV, Waddell N, Kassahn K, Gingras M-C, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch A-M, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, Gill AJ, Pinho AV, et al. Nature. 2012 Nov; doi:10.1038/nature11547 [PMID:23103869]
  2. RON is not a prognostic marker for resectable pancreatic cancer. Tactacan CM, Chang, DK, Cowley MJ, Humphrey ES, Wu J, Gill AJ, Chou A, Nones K, Grimmond SM, Sutherland RL, Biankin AV, Daly RJ and Australian Pancreatic Genome Initiative. BMC Cancer. 2012 Sep; doi:10.1186/1471-2407-12-395 [PMID:22958871]
  3. Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Rottenberg S, Vollebergh MA, de Hoon B, de Ronde J, Schouten PC, Kersbergen A, Zander SA, Pajic M, Jaspers JE, Jonkers M, Lodén M, Sol W, van der Burg E, Wesseling J, Gillet JP, Gottesman MM, Gribnau J, Wessels L, Linn SC, Jonkers J, Borst P. Cancer Res. 2012 May; doi:10.1158/0008-5472.CAN-11-4201 [PMID:22396490]
  4. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KAT, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM, APGI, Wessels LFA, Wood SA, Iacobuzio-Donahue CA, Pilarsky CA, Largaespada DA, Adams DJ, Tuveson DA. Nature. 2012 Apr; doi:10.1038/nature11114
  5. Sleeping Beauty Mutagenesis Reveals Cooperating Mutations and Pathways in Pancreatic Adenocarcinoma. Mann KM, Ward JM, Yew CCK, Kovochich A, Dawson DW, Black MA, Brett BT, Sheets TE, Dupuy AJ, Chang DK, Biankin AV, Waddell N, Khassan KS, Grimmond SM, APGI., Rust AG, Adams DJ, Jenkins NA, Copeland NG. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41. Epub 2012 Mar 15. [PMID: 22421440]
  6. The prognostic and predictive value of serum CA19.9 in pancreatic cancer. Humphris JL, Chang DK, Johns AL, Scarlett CJ, Pajic M, Jones MD, Colvin EK, Nagrial A, Chin VT, Chantrill LA, Samra JS, Gill AJ, Kench JG, Merrett ND, Das A, Musgrove EA, Sutherland RL and Biankin AV.  Ann Oncol. 2012 Jan 11. [PMID: 22241899]
  7. PINA v2.0 Mining Interactome modules. Cowley MJ, Pinese M, Kassahn KS, Waddell N, Pearson JV, Grimmond SM, Biankin AV, Hautaniemi S, Wu J. PINA v2.0: Nucleic Acids Res. 2012 Jan; 40(Database issue):D862-5. [PMID: 22067443]
  8. Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction. Scarlett CJ, Colvin EK, Pinese M, Chang DK, Morey AL, Musgrove EA, Pajic M, Apte M, Henshall SM, Sutherland RL, Kench JG, Biankin AV. LoS One. 2011;6(10):e26088. [PMID: 22022519]
  9. Molecular diagnostics in pancreatic cancer, Advances in Pancreatic Cancer Treatment. Chang DK, Grimmond SM, Biankin AV: Future Medicine Ltd, 2011, pp 20-35. doi: 10.2217/9781780840703
  10. Clinical and immunohistochemical features of 34 solid pseudopapillary tumours of the pancreas. Nguyen NQ, Johns AL, Gill AJ, Ring N, Chang DK, Clarkson A, Merrett ND, Kench JG, Colvin EK, Scarlett CJ and Biankin AV (2011). J Gastroenterol Hepatol. 2011 Feb;26(2):267-74. doi: 10.1111/j.1440-1746.2010.06466.x. [PMID: 21261715]
  11. Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes. Pajic M, Scarlett CJ, Chang DK, Sutherland RL and Biankin AV (2011). Hum Genet. 2011 Jul;130(1):93-101. Epub 2011 Apr 23. [PMID: 21516344]
  12. Precursor lesions in pancreatic cancer: morphological and molecular pathology. Scarlett CJ, Salisbury EL, Biankin AV and Kench JG (2011). Pathology. 2011 Apr;43(3):183-200. [PMID: 21436628]
  13. “How to Treat” Pancreatic Disease. Chang DK,Pavey DA, Biankin AV.  Australian Doctor. 10th June, 2011
  14. International network of cancer genome projects. The International Cancer Genome Consortium (2010). Nature. 2010 Apr 15;464(7291):993-8. [PMID: 20393554].
  15. Margin clearance and outcome in resected pancreatic cancer. Chang DK. Johns AL. Merrett ND. Gill AJ. Colvin EK. Scarlett CJ. Nguyen NQ. Leong RW. Cosman PH. Kelly MI. Sutherland RL. Henshall SM. Kench JG. Biankin AV. J Clin Oncol. 2009 Jun 10;27(17):2855-62. Epub 2009 Apr 27. [PMID: 19398572].
  16. Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Biankin AV. Kench JG. Colvin EK. Segara D. Scarlett CJ. Nguyen NQ. Chang DK. Morey AL. Lee CS. Pinese M. Kuo SC. Susanto JM. Cosman PH. Lindeman GJ. Visvader JE. Nguyen TV. Merrett ND. Musgrove EA. Henshall SM. Sutherland RL. Gastroenterology. 2009 Aug;137(2):558-68, 568.e1-11. [PMID: 19376121].